Run Python Notepad++ -------------------- Run Run... (F5) "%ComSpec%" /c "cd /d "$(CURRENT_DIRECTORY)"&"C:\Program Files\Python37\python.exe" "$(FILE_NAME)"&echo.&echo.&pause" [Save...] Name: Run Python Shortcut: Ctrl + F5 (or edit) %APPDATA%\Notepad++\shortcuts.xml "%ComSpec%" /c "cd /d "$(CURRENT_DIRECTORY)"&"C:\Program Files\Python37\python.exe" "$(FILE_NAME)"&echo.&echo.&pause" File Open... (Ctrl+O) python-run-test.py ( http://wiki.vkuthan.cz/python/python-run-test.py ) Run Python (Ctrl+F5) Both paths have to be same